SR 9009 is a Rev-ErbA agonist. This unique receptor acts as a nuclear hormone receptor affecting transcription of proteins and is encoded by similar transcripts as the thyroid hormone receptor. By activating this receptor, SR 9009 physiologically increases work capacity by turning up the production of mitochondria within skeletal muscle. Mitochondria are responsible for oxidative phosphorylation, which is the process by which our cells create and store energy.
All the effects observed for SR 9009 derive from Rev-Erb activation in the body. Rev-Erb affects the circadian behavior of mice, altering their activity and sleep patterns. Besides its effect on the circadian rhythm (suppression of BMAL1 production), Rev-Erb affects many other functions related to energy production. Rev-Erb is mainly found in liver, muscle, and fat tissue. In the liver, Rev-Erb affects the rhythm of 90% of the about 900 genes under circadian control in mice liver. It turns off the genes that produce glucose without altering insulin sensitivity. It also turns on genes that generate new fat cells and reduces the inflammatory response (by affecting macrophage production). In muscles, Rev-Erb promotes the burning of fat, increases the activity of mitochondria, and promotes the generation of new while decreasing the destruction of old mitochondria. In fat tissue, Rev-Erb turns off the genes responsible for storing fat and decreases triglyceride production.
What this compound does is it stimulates and activates the Rev-ErbA, which increases mitochondria. Through the mechanisms above then leads to increased stamina, endurance, and exercise capacity. It’s the main reason why bodybuilders and athletes research this product. It could significantly enhance endurance and fat loss. When we look at animal studies done with this compound, SR 9009 is shown to boost exercise capacity. By boosting exercise capacity, you’ll be able to push on for longer. Cardio will become more relaxed, and you’ll be able to get more work done. Making cardio easier is extremely interesting for many of us. Not only will more cardio supercharge fat loss, but it’s also suitable for your cardiovascular system.
SR 9009, also known as Stenabolic, is effective at improving endurance, potential for fat loss, and overall energy at a dose of 20mg daily. Because SR 9009 is non-hormonal, there is no need for an aromatase inhibitor or selective estrogen receptor modulator for estrogenic support. The half-life of SR 9009 is only roughly 4 to 5 hours. The half-life is extremely short, and you will have to dose multiple times per day to reap the compounds’ benefits. For example, let’s say your dosage is 20mg per day. That means you would have to take 10mg doses every 8-10 hours.